Genome Resource Facility
ثبت نشده
چکیده
DNA microarray technology (also known as DNA arrays, DNA chips or biochips) represents one of the latest breakthroughs and indeed major achievements in experimental molecular biology. This novel technology, which started to appear during the second half of the 1990s, has historically evolved from the initial experimental reports published in the mid 1970s which indicated that labelled nucleic acids could be used to monitor the expression of nucleic acid molecules attached to a solid support. However, it was not until 1995 that the first article describing the application of DNA microarray technology to expression analysis was published in the scientific literature by Patrick Brown and his colleagues at Stanford University (Brown., et al. 1995).
منابع مشابه
ASPIC: a web resource for alternative splicing prediction and transcript isoforms characterization
Alternative splicing (AS) is now emerging as a major mechanism contributing to the expansion of the transcriptome and proteome complexity of multicellular organisms. The fact that a single gene locus may give rise to multiple mRNAs and protein isoforms, showing both major and subtle structural variations, is an exceptionally versatile tool in the optimization of the coding capacity of the eukar...
متن کاملxBASE2: a comprehensive resource for comparative bacterial genomics
xBASE is a genome database aimed at helping laboratory-based bacteriologists make best use of bacterial genome sequence data, with a particular emphasis on comparative genomics. The latest version, xBASE 2.0 (http://xbase.bham.ac.uk), now provides comprehensive coverage of all bacterial genomes and features an updated modularized backend and an improved user interface, which includes a taxonomy...
متن کاملFrom Sequencer to Supercomputer: An Automatic Pipeline for Managing and Processing Next Generation Sequencing Data
Next Generation Sequencing is highly resource intensive. NGS Tasks related to data processing, management and analysis require high-end computing servers or even clusters. Additionally, processing NGS experiments requires suitable storage space and significant manual interaction. At The Ohio State University's Biomedical Informatics Shared Resource, we designed and implemented a scalable archit...
متن کاملCrisprGE: a central hub of CRISPR/Cas-based genome editing
CRISPR system is a powerful defense mechanism in bacteria and archaea to provide immunity against viruses. Recently, this process found a new application in intended targeting of the genomes. CRISPR-mediated genome editing is performed by two main components namely single guide RNA and Cas9 protein. Despite the enormous data generated in this area, there is a dearth of high throughput resource....
متن کاملEstablishing a Fair Price for Steam from a Resource Recovery Facility
The economic feasibility of resource recovery projects depends largely on the amount of revenue that can be obtained from the recovered energy products. The revenue that can be obtained from steam is dependent on the type of steam market available. The type of steam market in turn affects the design of the resource recovery facility and its capital cost. This paper discusses how the proposed st...
متن کاملREFGEN and TREENAMER: Automated Sequence Data Handling for Phylogenetic Analysis in the Genomic Era
The phylogenetic analysis of nucleotide sequences and increasingly that of amino acid sequences is used to address a number of biological questions. Access to extensive datasets, including numerous genome projects, means that standard phylogenetic analyses can include many hundreds of sequences. Unfortunately, most phylogenetic analysis programs do not tolerate the sequence naming conventions o...
متن کامل